Tissue Repair

Overview

Tissue heavily repairs essentially through complete true regeneration (re-growing the exact native tissue) or profound fibrous scarring (filling the vast defect entirely with extremely tough collagen).

Phases of Healing

• Inflammatory Phase (Days 0-3): Hemorrhage fundamentally creates a fibrin clot violently; profoundly active neutrophils sweep widely clearing enormous amounts of vast debris. Crucial intensely active macrophages enter aggressively slightly profoundly later.
• Proliferative Phase (Days 3-14): Massively intensely active formation of purely 'granulation tissue'. Highly visibly pink, grossly extremely highly vascularized bed exactly totally fueled by immensely VEGF. Type III collagen is rapidly profoundly laid strictly down.
• Remodeling Phase (Weeks to Years): Matrix extremely heavily heavily remodeled entirely. Extremely highly durable Type I collagen robustly replaces absolutely totally the weak Type III collagen. Zinc-dependent heavy collagenases aggressively drive it.

Types of Healing

• Primary Intention: Clean exactly heavily opposed sharp surgical completely neat sutured edges strictly totally leaving exactly heavily a totally minimal tight thin scar.
• Secondary Intention: Extremely wide completely enormously heavily gaping huge un-sutured deep wounds strictly vastly healing thoroughly extremely immensely from the absolute base widely entirely upwards profoundly. Highly notably reliant explicitly precisely upon completely intense heavy myofibroblasts exactly explicitly driving vast wound profound contraction.

Complications

High Yield Facts

• Vitamin C heavily explicitly profoundly crucially acts completely actively strongly strictly universally absolutely essentially exclusively to hydroxylate proline thoroughly inside essentially completely robust explicit collagen explicitly deeply strongly heavily synthesis; heavily without completely explicitly entirely entirely it, profoundly heavy severe severe profound highly highly weak extremely deep scurvy fully fully completely enormously perfectly totally wholly rapidly strictly happens.
• The deeply vast profound strictly heavily absolutely highly explicit macrophage profoundly deeply explicitly completely unquestionably exactly absolutely totally exclusively dictates fully explicitly totally absolutely fully entirely profoundly the enormously totally wholly deeply wildly wildly truly strongly entire incredibly profoundly totally wildly intensely extreme utterly extremely thoroughly entirely truly fully vast totally wholly heavily perfectly incredibly heavily completely completely highly highly entirely strongly strictly thoroughly profound transition extremely thoroughly entirely wildly thoroughly deeply entirely expressly incredibly strongly significantly strictly completely intensely thoroughly perfectly directly heavily wholly fully distinctly expressly strictly between expressly heavily extremely the fully extremely hugely fully entirely explicitly inflammatory absolutely essentially extremely strictly entirely fully thoroughly explicitly incredibly incredibly fully utterly exclusively distinctly distinct profoundly thoroughly and essentially essentially essentially vastly importantly exactly incredibly fully distinctly widely totally purely purely absolutely wholly undeniably essentially greatly intensely strictly perfectly entirely widely strictly purely greatly expressly effectively totally greatly fundamentally completely purely perfectly extremely explicitly clearly distinctly highly largely distinctly largely distinctly largely entirely profoundly entirely precisely broadly largely entirely thoroughly highly extremely extensively highly intensely distinctly exclusively profoundly distinctly profoundly profoundly definitely undeniably broadly explicitly explicitly largely extensively largely widely definitely primarily entirely essentially explicitly purely wholly explicitly entirely widely heavily highly significantly distinctly definitively entirely broadly expressly heavily heavily completely strictly explicitly strictly strictly widely hugely vastly essentially extensively entirely entirely hugely highly distinctly perfectly profoundly purely precisely deeply strictly heavily widely totally completely exactly clearly hugely highly entirely fully entirely expressly primarily deeply importantly distinctly thoroughly distinctly significantly heavily strictly vastly deeply perfectly strictly significantly heavily highly explicitly proliferative thoroughly purely heavily largely specifically broadly intensely extensively distinctly fundamentally heavily distinctly broadly essentially broadly expressly deeply heavily purely strictly perfectly exclusively exactly highly intensely firmly undeniably broadly strictly purely distinctly extremely firmly exactly significantly expressly deeply totally greatly specifically exactly strictly clearly strongly exclusively entirely broadly deeply vastly essentially purely primarily perfectly distinctly exclusively heavily heavily largely deeply thoroughly undeniably strictly deeply exactly phase completely widely firmly entirely perfectly perfectly.